> ## Documentation Index
> Fetch the complete documentation index at: https://docs.synthesize.bio/llms.txt
> Use this file to discover all available pages before exploring further.

# Start generating genomics data with Synthesize Bio

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    <div className="text-5xl mb-6 leading-[1.2] font-normal text-gray-800 dark:text-white">
      Start building <br />with Synthesize Bio
    </div>

    <div className="text-2xl dark:text-gray-300">
      Generative models for human gene expression — predict bulk and single-cell profiles across tissues, cell types, perturbations, and disease states from metadata alone.
    </div>

    <div className="text-lg mt-6">
      Available through Python and R SDKs, MCP-compatible tools, and the web.
    </div>

    <CardGroup cols={3} className="mt-6">
      <Card title="Quickstart" icon="rocket" href="/get-started/quickstart" horizontal />

      <Card title="API key" icon="key" href="/get-started/quickstart" horizontal />
    </CardGroup>
  </Column>

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    <Tabs className="my-code-tabs">
      <Tab title="Python">
        ```python theme={null}
        import pysynthbio

        # Get an example query
        query = pysynthbio.get_example_query(model_id="gem-1-bulk")["example_query"]

        # Generate a dataset
        result = pysynthbio.predict_query(query, model_id="gem-1-bulk")

        # Access the results
        metadata = result["metadata"]
        expression = result["expression"]
        ```
      </Tab>

      <Tab title="R">
        ```r theme={null}
        library(rsynthbio)

        # Get an example query
        query <- get_example_query(model_id = "gem-1-bulk")$example_query

        # Generate a dataset
        result <- predict_query(query, model_id = "gem-1-bulk")

        # Access the results
        metadata <- result$metadata
        expression <- result$expression
        ```
      </Tab>
    </Tabs>
  </Column>
</Columns>

<CardGroup cols={4} className="mt-8">
  <Card href="/pysynthbio">
    <div className="not-prose dark:text-white font-semibold flex gap-2 items-center">
      <img src="https://mintcdn.com/synthesizebio/Ru43cFGiLvcTzUS3/images/entrypoint-python.svg?fit=max&auto=format&n=Ru43cFGiLvcTzUS3&q=85&s=4878445da113651d1feb0344bc1d3798" alt="Python logo" className="my-0 size-6 shrink-0" width="24" height="24" data-path="images/entrypoint-python.svg" />

      <span>Python SDK</span>
    </div>

    Use **pysynthbio** to predict gene expression from your Python notebooks and pipelines. Jump to the [Python SDK](/pysynthbio) or start from the [Quickstart](/get-started/quickstart).
  </Card>

  <Card href="/rsynthbio">
    <div className="not-prose dark:text-white font-semibold flex gap-2 items-center">
      <img src="https://mintcdn.com/synthesizebio/Ru43cFGiLvcTzUS3/images/entrypoint-r.svg?fit=max&auto=format&n=Ru43cFGiLvcTzUS3&q=85&s=2f503c875982621d96e8c845c7c1082a" alt="R logo" className="my-0 size-6 shrink-0" width="24" height="24" data-path="images/entrypoint-r.svg" />

      <span>R SDK</span>
    </div>

    Use **rsynthbio** to predict gene expression from your R notebooks and pipelines. Jump to the [R SDK](/rsynthbio) or start from the [Quickstart](/get-started/quickstart).
  </Card>

  <Card href="/platform">
    <div className="not-prose dark:text-white font-semibold flex gap-2 items-center">
      <img src="https://mintcdn.com/synthesizebio/Ru43cFGiLvcTzUS3/images/entrypoint-mcp.svg?fit=max&auto=format&n=Ru43cFGiLvcTzUS3&q=85&s=039be86975528951e453e5f1dc335bd8" alt="MCP logo" className="my-0 size-6 shrink-0" width="24" height="24" data-path="images/entrypoint-mcp.svg" />

      <span>MCP</span>
    </div>

    Use MCP-compatible AI tools to predict gene expression and chat about your results.
  </Card>

  <Card href="https://app.synthesize.bio">
    <div className="not-prose dark:text-white font-semibold flex gap-2 items-center">
      <img src="https://mintcdn.com/synthesizebio/Ru43cFGiLvcTzUS3/images/entrypoint-platform.svg?fit=max&auto=format&n=Ru43cFGiLvcTzUS3&q=85&s=6541edc3e08f5f9b8aed6a5aada93236" alt="Synthesize Bio logo" className="my-0 size-6 shrink-0" width="225" height="225" data-path="images/entrypoint-platform.svg" />

      <span>Platform</span>
    </div>

    Low- and no-code exploration in the browser — no local install required.
  </Card>
</CardGroup>

## About our models

Generate synthetic gene expression profiles from metadata alone, then use them in downstream analysis and integration workflows.

<CardGroup cols={3}>
  <Card title="GEM-1 bulk" icon="chart-column">
    Baseline model for predicting **bulk** gene expression.
  </Card>

  <Card title="GEM-1 single-cell" icon="microscope">
    Baseline model for predicting **single-cell** gene expression.
  </Card>

  <Card title="GEM-2" icon="sparkles">
    **Coming soon** — next-generation capabilities. Check the [platform](https://app.synthesize.bio) and these docs for updates.
  </Card>
</CardGroup>

## Advanced platform capabilities

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  <Card title="Reference conditioning" icon="link">
    Anchor generation to an existing, real reference sample while you apply perturbations or other modifications.
  </Card>

  <Card title="Metadata prediction" icon="tags" href="/get-started/available-metadata">
    Predict or infer biological characteristics such as cell type, tissue, disease state, and more. Vocabularies and fields are model-specific — see [Available metadata](/get-started/available-metadata).
  </Card>
</CardGroup>

Reach out to [partnerships@synthesize.bio](mailto:partnerships@synthesize.bio) if you are interested in trying out the advanced capabilities.

## Support

<CardGroup cols={2}>
  <Card title="Schedule a meeting" icon="calendar" href="mailto:support@synthesize.bio?subject=Schedule%20a%20meeting%20%28docs%29">
    Email us to set up time with the team.
  </Card>

  <Card title="Email us" icon="envelope" href="mailto:support@synthesize.bio">
    [support@synthesize.bio](mailto:support@synthesize.bio) for product and integration questions.
  </Card>
</CardGroup>