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This guide takes you from zero to a working API call in about five minutes. Pick the SDK or integration that matches your environment at the end.
1

Create an account

Sign up at app.synthesize.bio and verify your email.
2

Generate an API key

In the platform, open Settings → API keys and click Create key. Copy the key somewhere safe — you won’t be able to view it again.
Treat the key like a password. Set it as an environment variable rather than checking it into source control:
export SYNTHBIO_API_KEY="sk-..."
3

Pick how you want to call the platform

pip install pysynthbio

from pysynthbio import SynthbioClient

client = SynthbioClient()  # picks up SYNTHBIO_API_KEY
models = client.list_models()
print(models[0])
See the Python SDK docs for the full reference.
4

Make your first prediction

Once list_models() returns results, you have a working connection. Pick a model_id and use get_example_query(model_id=...) to generate a starter request you can adapt to your data.Need to know which metadata fields a model accepts? See Available metadata. Want to understand public dataset inputs? See Public dataset preprocessing.

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Available metadata

Browse the metadata vocabularies that each model accepts.

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What’s next?

Python SDK reference

Full pysynthbio reference and recipes.

R SDK reference

Full rsynthbio reference and recipes.

MCP setup

Connect Synthesize Bio to Claude, Cursor, and other MCP clients.